I've never had a chance to play in a humans only D&D game (or any other game for that matter). For all of the human-centric world building in the various editions, no one was ever interested.
Yet it gets talked about fairly often, and really humans make great villans! I can't think of any reason it wouldn't work... Especially for the right type of game.
But would it work for out of the box D&D? Keeping in all the monsters, magic and everything?
How many of you have played or ran a humans only game? How did it go? Inquiring minds want to know...
And for those who don't want to leave a comment, there's a handy little poll off to the side.